Human CLC-KB gene promoter drives the EGFP expression in the specific distal nephron segments and inner ear.

@article{Kobayashi2002HumanCG,
  title={Human CLC-KB gene promoter drives the EGFP expression in the specific distal nephron segments and inner ear.},
  author={Katsuki Kobayashi and Shinichi Uchida and Hiro-oki Okamura and Fumiaki Marumo and Sei Sasaki},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2002},
  volume={13 8},
  pages={1992-8}
}
Human CLC-KB has been identified as a kidney-specific member of the CLC chloride channel family, and mutations of the human CLC-KB gene are known to cause Bartter syndrome type III. A precise understanding of the localization of this channel in the human kidney is imperative to our understanding of the pathophysiology, but this has remained unclear due to the high homology between human CLC-KB and CLC-KA, another kidney-specific member of the same family. The high intraspecies homology also… CONTINUE READING

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