Human CHMP6, a myristoylated ESCRT-III protein, interacts directly with an ESCRT-II component EAP20 and regulates endosomal cargo sorting.

@article{Yorikawa2005HumanCA,
  title={Human CHMP6, a myristoylated ESCRT-III protein, interacts directly with an ESCRT-II component EAP20 and regulates endosomal cargo sorting.},
  author={Chiharu Yorikawa and Hideki Shibata and Satoshi Waguri and Kazumi Hatta and Mio Horii and Keiichi Katoh and Toshihide Kobayashi and Yasuo Uchiyama and Masatoshi Maki},
  journal={The Biochemical journal},
  year={2005},
  volume={387 Pt 1},
  pages={17-26}
}
CHMP6 (charged multivesicular body protein 6) is a human orthologue of yeast Vps (vacuolar protein sorting) 20, a component of ESCRT (endosomal sorting complex required for transport)-III. Various CHMP6 orthologues in organisms ranging from yeast to humans contain the N-myristoylation consensus sequence at each N-terminus. Metabolic labelling of HEK-293 (human embryonic kidney) cells showed the incorporation of [3H]myristate into CHMP6 fused C-terminally to GFP (green fluorescent protein… CONTINUE READING