Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere

@article{Sullivan1994HumanCC,
  title={Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere},
  author={Kevin F. Sullivan and Mirko Hechenberger and K A Masri},
  journal={The Journal of Cell Biology},
  year={1994},
  volume={127},
  pages={581 - 592}
}
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. To examine the molecular basis for the specification of centromeric chromatin, we have cloned a human cDNA that encodes the 17-kD histone-like centromere antigen, CENP-A. Two domains are evident in the 140 aa CENP-A polypeptide: a unique NH2-terminal domain and a 93-amino acid COOH-terminal domain that shares 62% identity with nucleosomal core protein, histone H3. An epitope tagged… CONTINUE READING
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Purification of the centromere-specific protein CENP-A and demonstration that it is a distinctive histone.

Proceedings of the National Academy of Sciences of the United States of America • 1991
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