Human CD8+ T cell responses to EBV EBNA1: HLA class I presentation of the (Gly-Ala)-containing protein requires exogenous processing.

@article{Blake1997HumanCT,
  title={Human CD8+ T cell responses to EBV EBNA1: HLA class I presentation of the (Gly-Ala)-containing protein requires exogenous processing.},
  author={Neil W. Blake and Sunray Lee and Irina Redchenko and Winston Thomas and N. Steven and Alison M. Leese and Patty M. Steigerwald-Mullen and Michael G. Kurilla and Lori Frappier and Alan B. Rickinson},
  journal={Immunity},
  year={1997},
  volume={7 6},
  pages={791-802}
}
Epstein-Barr virus (EBV)-induced cytotoxic T lymphocyte (CTL) responses have been detected against many EBV antigens but not the nuclear antigen EBNA1; this has been attributed to the presence of a glycine-alanine repeat (GAr) domain in the protein. Here we describe the isolation of human CD8+ CTL clones recognizing EBNA1-specific peptides in the context of HLA-B35.01 and HLA-A2.03. Using these clones, we show that full-length EBNA1 is not presented when expressed endogenously in target cells… CONTINUE READING

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