Human CD5+ B lymphocytes (B-1 cells) decrease in peripheral blood during pregnancy.


Pregnancy is a unique immunologic state where a natural homeostasis exists between antigenically different tissues. Several earlier studies have addressed the fluctuations in the number and/or function of lymphocytes, including B cells during pregnancy, but changes within the subsets of B lymphocytes, conventional (CD5-) and B-1 (CD5+), have not been addressed. Here we demonstrate that the frequency of B-1 cells decreases dramatically during pregnancy, whereas the frequency of conventional B cells remains relatively constant. The missing B-1 cells return to pre-pregnancy levels 8-10 weeks after parturition. The polyreactive autoantibodies secreted by B-1 cells have been implicated in autoimmunity and immune regulation. The possible role of B-1 cells during pregnancy will be discussed in that context.

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@article{Bhat1995HumanCB, title={Human CD5+ B lymphocytes (B-1 cells) decrease in peripheral blood during pregnancy.}, author={Neelima M Bhat and Aditya Mithal and Marcia M. Bieber and L. A. Herzenberg and Nelson N. H. Teng}, journal={Journal of reproductive immunology}, year={1995}, volume={28 1}, pages={53-60} }