Human CD4 "internal antigen" mimicry by anti-idiotypic monoclonal antibodies.

  title={Human CD4 "internal antigen" mimicry by anti-idiotypic monoclonal antibodies.},
  author={Federico Perosa and Franco Dammacco},
  journal={International journal of clinical & laboratory research},
  volume={24 1},
Of 1019 hybridomas generated from a BALB/c mouse immunized with the syngeneic anti-CD4 monoclonal antibody HP2/6, 3 were found to secrete anti-idiotypic antibodies. Detailed analysis of anti-idiotypic monoclonal antibodies F16-10F6, F16-14D6 and F16-16D7 showed they recognize idiotope(s) not expressed by any of the anti-CD4 monoclonal antibodies tested, including those which inhibit the binding of HP2/6 to CD4 antigen. The idiotope recognized by the three anti-idiotypic antibodies are within… CONTINUE READING