Human CD4+CD25+ regulatory cells have marked and sustained effects on CD8+ T cell activation.

@article{Cmara2003HumanCR,
  title={Human CD4+CD25+ regulatory cells have marked and sustained effects on CD8+ T cell activation.},
  author={Niels Olsen Saraiva C{\^a}mara and Fabien S{\'e}bille and R. Lechler},
  journal={European journal of immunology},
  year={2003},
  volume={33 12},
  pages={3473-83}
}
Amongst the many types of regulatory cells that have been described during the past few years, the spontaneously occurring population that is characterized by co-expression of CD4 and CD25 appears to play a key role in the prevention of autoimmunity and the maintenance of transplantation tolerance. In this study we have examined the ability of CD4(+)CD25(+) T cells to regulate human CD8(+) T cells, and the behavior of CD8(+) T cells following activation in the presence of regulatory CD4(+)CD25… CONTINUE READING