Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro.

@article{Stephens2001HumanCT,
  title={Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro.},
  author={Leigh Andrea Stephens and Christian Mottet and Don Mason and Fiona Powrie},
  journal={European journal of immunology},
  year={2001},
  volume={31 4},
  pages={1247-54}
}
CD4(+)CD25(+) T cells in mice and rats are capable of transferring protection against organ-specific autoimmune disease and colitis and suppressing the proliferation of other T cells after polyclonal stimulation in vitro. Here we describe the existence in humans of CD4(+)CD25(+) T cells with the same in vitro characteristics. CD4(+)CD8(-)CD25(+) T cells are present in both the thymus and peripheral blood of humans ( approximately 10 % of CD4(+)CD8(-) T cells), proliferate poorly in response to… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 196 extracted citations

Phenotype, Localization, and Mechanism of Suppression of CD4+CD25+ Human Thymocytes

The Journal of experimental medicine • 2002
View 5 Excerpts
Highly Influenced

Factors regulating apoptosis and homeostasis of CD4+ CD25(high) FOXP3+ regulatory T cells are new therapeutic targets.

Frontiers in bioscience : a journal and virtual library • 2008
View 5 Excerpts
Highly Influenced

Mechanisms of inflammation: the good, the bad and the ugly.

Frontiers in bioscience : a journal and virtual library • 2004
View 7 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…