Human CD34+ fetal liver stem cells differentiate to T cells in a mouse thymic microenvironment.

@article{Plum1994HumanCF,
  title={Human CD34+ fetal liver stem cells differentiate to T cells in a mouse thymic microenvironment.},
  author={Jean Plum and Magda de Smedt and Marie Paule Defresne and Georges Leclercq and Bart Vandekerckhove},
  journal={Blood},
  year={1994},
  volume={84 5},
  pages={1587-93}
}
Hematopoietic stem cells differentiate in the thymus to T cells along precisely defined intermediates. This process is thymic epithelium dependent and involves cytokines and cell-cell interactions between thymic stroma and T-cell precursors. Here we report that highly purified human CD34++ fetal liver stem cells differentiate to mature T cells, when seeded into isolated fetal thymic lobes of severe combined immunodeficient mice, and subsequently cultured in vitro. The human stem cells… CONTINUE READING