Human CD34(+) stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi.

@article{Sharma2001HumanCS,
  title={Human CD34(+) stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi.},
  author={Arjun Sharma and Michael C. Nelson and John E. Brandt and Maija Wessman and Nadim Mahmud and Kevin P. Weller and Ronald F. Hoffman},
  journal={Blood},
  year={2001},
  volume={97 2},
  pages={426-34}
}
Hematopoietic stem cells (HSCs) are characterized by their dual abilities to undergo differentiation into multiple hematopoietic cell lineages or to undergo self-renewal. The molecular basis of these properties remains poorly understood. Recently the piwi gene was found in the embryonic germline stem cells (GSCs) of Drosophila melanogaster and has been shown to be important in GSC self-renewal. This study demonstrated that hiwi, a novel human homologue of piwi, is also present in human CD34… CONTINUE READING
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Progress in the development of systems for in vitro expansion of human hematopoietic stem cells

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