Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells.

@article{Koenen2008HumanCR,
  title={Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells.},
  author={Hans J P M Koenen and Ruben L. Smeets and Paul M. Vink and Esther van Rijssen and Annemieke M. H. Boots and Irma Joosten},
  journal={Blood},
  year={2008},
  volume={112 6},
  pages={2340-52}
}
The effector T-cell lineage shows great plasticity. Th17 cells are acknowledged to be instrumental in the response against microbial infection, but are also associated with autoimmune inflammatory processes. Here, we report that human regulatory T cells (CD4(pos)CD25(high)Foxp3(pos)CD127(neg)CD27(pos)) can differentiate into IL-17-producing cells, when stimulated by allogeneic antigen-presenting cells, especially monocytes, in the presence of rhIL-2/rhIL-15. These regulatory T cell (Treg… CONTINUE READING
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Interleukin-23 promotes a distinct CD4 T-cell activation state characterized by the HUMAN Tregs DIFFERENTIATE INTO Th-17–LIKE CELLS

  • S Aggarwal, N Ghilardi, MH Xie, FJ de Sauvage, AL. Gurney
  • BLOOD,
  • 2008

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