Human CD 4 1 central and effector memory T cells produce IL-21 : effect on cytokine-driven proliferation of CD 4 1 T cell subsets

@inproceedings{Onoda2007HumanC4,
  title={Human CD 4 1 central and effector memory T cells produce IL-21 : effect on cytokine-driven proliferation of CD 4 1 T cell subsets},
  author={Tadashi Onoda and Mizanur Rahman and Hidetoshi Nara and Akemi Araki and Koki Makabe and Kouhei Tsumoto and Izumi Kumagai and Toshio Kudo and Naoto Ishii and Nobuyuki Tanaka and Kazuo Sugamura and Kiyoshi Hayasaka and Hironobu Asao},
  year={2007}
}
IL-21 regulates certain functions of T cells, B cells, NK cells and dendritic cells. Although activated CD4 T cells produce IL-21, data identifying the specific CD4 T cell subsets that produce IL-21 are conflicting. In a previous study, mouse IL-21 message was detected in TH2, whereas human IL-21 (hIL-21) message was found in both TH1 and follicular helper T cells. To identify the IL-21-secreting cell populations in human, we established a hybridoma cell line producing an anti-hIL-21 mAb… CONTINUE READING