Human CASK/LIN-2 Binds Syndecan-2 and Protein 4.1 and Localizes to the Basolateral Membrane of Epithelial Cells

@article{Cohen1998HumanCB,
  title={Human CASK/LIN-2 Binds Syndecan-2 and Protein 4.1 and Localizes to the Basolateral Membrane of Epithelial Cells },
  author={Alexandra R. Cohen and Daniel F. Wood and Shirin M. Marfatia and Zenta Walther and Athar H Chishti and James Melvin Anderson},
  journal={The Journal of Cell Biology},
  year={1998},
  volume={142},
  pages={129 - 138}
}
In Caenorhabditis elegans, mutations in the lin-2 gene inactivate the LET-23 receptor tyrosine kinase/Ras/MAP kinase pathway required for vulval cell differentiation. One function of LIN-2 is to localize LET-23 to the basal membrane domain of vulval precursor cells. LIN-2 belongs to the membrane-associated guanylate kinase family of proteins. We have cloned and characterized the human homolog of LIN-2, termed hCASK, and Northern and Western blot analyses reveal that it is ubiquitously expressed… CONTINUE READING
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