Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q.

@article{McGreal2002HumanCI,
  title={Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q.},
  author={Eamon Patrick McGreal and Nobunao Ikewaki and Hiroyasu Akatsu and Bryan Morgan and Philippe Gasque},
  journal={Journal of immunology},
  year={2002},
  volume={168 10},
  pages={
          5222-32
        }
}
It has been suggested that the human C1qRp is a receptor for the complement component C1q; however, there is no direct evidence for an interaction between C1q and C1qRp. In this study, we demonstrate that C1q does not show enhanced binding to C1qRp-transfected cells compared with control cells. Furthermore, a soluble recombinant C1qRp-Fc chimera failed to interact with immobilized C1q. The proposed role of C1qRp in the phagocytic response in vivo is also unsupported in that we demonstrate that… CONTINUE READING
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