Human C-type lectin domain family 4, member C (CLEC4C/BDCA-2/CD303) is a receptor for asialo-galactosyl-oligosaccharides.

@article{Riboldi2011HumanCL,
  title={Human C-type lectin domain family 4, member C (CLEC4C/BDCA-2/CD303) is a receptor for asialo-galactosyl-oligosaccharides.},
  author={Elena Riboldi and Roberta Daniele and Carmen Parola and Antonio Inforzato and Phoebe L Arnold and Daniela Bosisio and Daved H Fremont and Antonio Bastone and Marco Colonna and Silvano Sozzani},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 41},
  pages={
          35329-33
        }
}
Plasmacytoid dendritic cells are specialized in the production of type I interferon (type I IFN), which promotes antiviral and antitumor responses, as well as autoimmune disorders. Activation of type I IFN secretion depends on the pattern recognition receptors TLR7 and TLR9, which sense microbial RNA and DNA, respectively. Type I IFN production is modulated by several receptors, including the type II C-type lectin domain family 4, member C (CLEC4C). The natural ligand of CLEC4C is unknown. To… CONTINUE READING

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