Human C-reactive protein slows atherosclerosis development in a mouse model with human-like hypercholesterolemia.

@article{Kovcs2007HumanCP,
  title={Human C-reactive protein slows atherosclerosis development in a mouse model with human-like hypercholesterolemia.},
  author={Alexander I. Kov{\'a}cs and Per Tornvall and Roland Nilsson and Jesper Tegn{\'e}r and Anders Hamsten and Johan Bj{\"o}rkegren},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 34},
  pages={13768-73}
}
Increased baseline values of the acute-phase reactant C-reactive protein (CRP) are significantly associated with future cardiovascular disease, and some in vitro studies have claimed that human CRP (hCRP) has proatherogenic effects. in vivo studies in apolipoprotein E-deficient mouse models, however, have given conflicting results. We bred atherosclerosis-prone mice (Apob(100/100)Ldlr(-/-)), which have human-like hypercholesterolemia, with hCRP transgenic mice (hCRP(+/0)) and studied lesion… CONTINUE READING

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