Human C-reactive protein is protective against fatal Streptococcus pneumoniae infection in transgenic mice.

@article{Szalai1995HumanCP,
  title={Human C-reactive protein is protective against fatal Streptococcus pneumoniae infection in transgenic mice.},
  author={Alexander Szalai and David E. Briles and John E. Volanakis},
  journal={Journal of immunology},
  year={1995},
  volume={155 5},
  pages={2557-63}
}
C-reactive protein (CRP) is an acute phase protein with a well known association with infection and other inflammatory conditions. Studies with use of purified CRP in in vitro assays provided early evidence that CRP has antibacterial activity. Subsequently it was shown that passively administered human CRP can protect mice from lethal infection with Streptococcus pneumoniae. In this study, we extend these observations to an in vivo model of host resistance by using human CRP transgenic mice… CONTINUE READING
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