Human C-reactive protein increases cerebral infarct size after middle cerebral artery occlusion in adult rats.

Abstract

Human C-reactive protein (CRP), the classic acute phase plasma protein, increases in concentration after myocardial infarction and stroke. Human CRP binds to ligands exposed in damaged tissue and can then activate complement and its proinflammatory functions. In contrast, rat CRP, which binds to similar ligands, does not activate complement. In the present… (More)

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@article{Gill2004HumanCP, title={Human C-reactive protein increases cerebral infarct size after middle cerebral artery occlusion in adult rats.}, author={Ramanjit Gill and John A. Kemp and Caroline Sabin and Mark B Pepys}, journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism}, year={2004}, volume={24 11}, pages={1214-8} }