Human Breast Milk and Antiretrovirals Dramatically Reduce Oral HIV-1 Transmission in BLT Humanized Mice

@inproceedings{Wahl2012HumanBM,
  title={Human Breast Milk and Antiretrovirals Dramatically Reduce Oral HIV-1 Transmission in BLT Humanized Mice},
  author={Angela Wahl and Michael D. Swanson and Tomonori Nochi and Rikke M\orch Olesen and Paul W Denton and Morgan L. Chateau and J. V{\'i}ctor Garc{\'i}a},
  booktitle={PLoS pathogens},
  year={2012}
}
Currently, over 15% of new HIV infections occur in children. Breastfeeding is a major contributor to HIV infections in infants. This represents a major paradox in the field because in vitro, breast milk has been shown to have a strong inhibitory effect on HIV infectivity. However, this inhibitory effect has never been demonstrated in vivo. Here, we address this important paradox using the first humanized mouse model of oral HIV transmission. We established that reconstitution of the oral cavity… CONTINUE READING
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