Human Brain Organoids on a Chip Reveal the Physics of Folding.

Abstract

Human brain wrinkling has been implicated in neurodevelopmental disorders and yet its origins remain unknown. Polymer gel models suggest that wrinkling emerges spontaneously due to compression forces arising during differential swelling, but these ideas have not been tested in a living system. Here, we report the appearance of surface wrinkles during the in… (More)
DOI: 10.1038/s41567-018-0046-7

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