Human Bocavirus Infection in Children With Respiratory Tract Disease

  title={Human Bocavirus Infection in Children With Respiratory Tract Disease},
  author={Natalie Brieu and Ga{\"e}l Guyon and Michel Rodi{\`e}re and Michel Segondy and Vincent Foulongne},
  journal={The Pediatric Infectious Disease Journal},
Background: Human bocavirus (HBoV) is a ubiquitous, newly described member of the Parvoviridae family frequently detected in the respiratory tract of children, but only few reports provide data proving the link between HBoV and respiratory tract disease (RTD). Objectives: To evaluate the incidence of HBoV infection in children with RTD; to analyze the clinical features of HBoV infection; and to clinically compare HBoV, respiratory syncytial virus (RSV), and human metapneumovirus (HMPV… 

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HBoV was frequently detected in nasopharyngeal aspirates from children with airway infections in Norway, andSemiquantitive PCR results may be useful for interpretation of clinical relevance.

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HBoV is one of the most prevalent respiratory viruses and plays an important role in respiratory illness in children, especially in terms of HBoV load.

Human bocavirus infection in young children with acute respiratory tract infection in Lanzhou, China†

HBoV is frequent in young children with acute respiratory tract infection in Lanzhou, China, and RSV is the most common coinfecting virus, and the NP‐1 gene was highly conserved in HBoV.

[Human bocavirus in Chile: clinical characteristics and epidemiological profile in children with acute respiratory tract infections].

HBoV was found either in symptomatic and asymptomatic children and the severity of the disease was greater when H BoV was associated to other respiratory viruses.

High frequency of human bocavirus 1 DNA in infants and adults with lower acute respiratory infection.

The results suggest that H BoV1 is involved in acute respiratory disease and Interplay between HBoV1 and RSV cannot be discarded as a cause of elevated percentages of co-detections in infants.

Human Bocavirus in Nasopharyngeal Secretion of Hospitalized Children with Acute Respiratory Tract Infection – First Year Results of a Four-Year Prospective Study

Human bocavirus, although often detected in combination with other respiratory viruses, is one of the possible causes of ARI in children and continuous laboratory detection of HBoV in the respiratory secretion of children with ARI is required to complete the findings on clinical significance and epidemiology of this infection.

Human bocavirus and other respiratory viral infections in a 2‐year cohort of hospitalized children†

Human bocavirus seems to be an important and frequent pathogen in respiratory tract infections in children, and it is likely that the severity of illness is comparable toThe severity of RSV illness.

Human bocaviruses: Possible etiologic role in respiratory infection.

Distinctive clinical features of human bocavirus in children younger than 2 years

HBoV-single positive patients show several clinical characteristics, such as seasonality, age, hypoxia, and neutrophilia, which differ from those with RSV infection.



Frequent detection of bocavirus DNA in German children with respiratory tract infections

HBoV is frequently found in NPAs of hospitalized infants and children with acute respiratory tract diseases, and application of some of Koch's revised postulates is not possible because of the high rate of coinfections with hBoV and other respiratory tract pathogens.

Human Bocavirus Infection in Young Children in the United States: Molecular Epidemiological Profile and Clinical Characteristics of a Newly Emerging Respiratory Virus

HBoV is circulating in the United States and is associated with both upper and lower respiratory tract disease in infants and young children.

Human Bocavirus in Hospitalized Children, South Africa

This retrospective study screened children hospitalized with respiratory tract infections in 2004 for common respiratory viruses, including respiratory syncytial virus; influenza virus A and B; parainfluenza viruses 1, 2, and 3; adenovirus; and cytomegalovirus for Parvovirus B19 and HBoV.

Human Bocavirus and Acute Wheezing in Children

  • T. AllanderT. Jartti O. Ruuskanen
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2007
Results suggest a model for bocavirus infection in which high viral loads are potentially associated with respiratory symptoms and low viral loads indicate asymptomatic shedding, and quantitative polymerase chain reaction analysis may be important for additional studies of human bocvirus.

Epidemiological Profile and Clinical Associations of Human Bocavirus and Other Human Parvoviruses

In the present study, HBoV was a frequently detected, potential respiratory pathogen, with a prevalence and an epidemiological profile comparable to those of RSV.

Human Bocavirus: Prevalence and Clinical Spectrum at a Children's Hospital

Human bocavirus DNA is commonly present in children with upper and lower respiratory tract infections and the presence of a pertussis-like cough and diarrhea in association with HBoV infection merits further investigation.

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HBoV infection was epidemiologically associated with pneumonia among young children in rural Thailand, but infection and illness may be dependent on coinfection with other viruses.

Clinical and Molecular Epidemiology of Human Bocavirus in Respiratory and Fecal Samples from Children in Hong Kong

Human bocavirus was detected in fecal specimens in children with acute gastroenteritis and a single lineage of HBoV was associated with both respiratory tract and enteric infections.

Seroepidemiology of Human Bocavirus in Hokkaido Prefecture, Japan

HBoV is a ubiquitous virus acquired early in life and that HBoV might play a role in the course of lower respiratory tract infections.

Detection of Human Bocavirus in Children Hospitalized because of Acute Gastroenteritis

The prevalence of human bocavirus in children with gastroenteritis was investigated to investigate the prevalence of hBoV and viral etiologic agents detected, suggesting that it might play a minor role in Gastroenteritis.