Human Blood – Brain Barrier Receptors for Alzheimer ’ s Amyloid-b 1 – 40 Asymmetrical Binding , Endocytosis , and Transcytosis at the Apical Side of Brain Microvascular Endothelial Cell Monolayer

Abstract

A soluble monomeric form of Alzheimer’s amyloidb (1–40) peptide (sA b 1–40 ) is present in the circulation and could contribute to neurotoxicity if it crosses the brain capillary endothelium, which comprises the blood–brain barrier (BBB) in vivo. This study characterizes endothelial binding and transcytosis of a synthetic peptide homologous to human sA b 1… (More)

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