Human Bioavailability and Pharmacokinetic Profile of Different Formulations Delivering Alpha Lipoic Acid

  title={Human Bioavailability and Pharmacokinetic Profile of Different Formulations Delivering Alpha Lipoic Acid},
  author={Fiorenzo Mignini and Cinzia Nasuti and Giuseppe Gioventu and Napolioni and Piera Di Martino},
  journal={Journal of clinical \& cellular immunology},
ALA exhibits this activity in both the reduced and oxidated forms. Lipoic acid is a racemic mixture. The redox couple α-lipoic/dihydrolipoic acid containing the R-enantiomer is covalently bound to a lysine residue, forming an essential lipoamide, which functions as a co-enzyme for the E2 subunit of four multi-enzymatic mitochondrial complexes, for example pyruvate dehydrogenase [1-6]. After administration, ALA is reduced at the intracellular level by various enzymes and released into the… 

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