Human Beta-Defensin 3 Is Up-Regulated in Cutaneous Leprosy Type 1 Reactions

Abstract

BACKGROUND Leprosy, a chronic granulomatous disease affecting the skin and nerves, is caused by Mycobacterium leprae (M. leprae). The type of leprosy developed depends upon the host immune response. Type 1 reactions (T1Rs), that complicate borderline and lepromatous leprosy, are due to an increase in cell-mediated immunity and manifest as nerve damage and… (More)
DOI: 10.1371/journal.pntd.0001869

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