Human Bence Jones protein toxicity in rat proximal tubule epithelium in vivo.

@article{Sanders1987HumanBJ,
  title={Human Bence Jones protein toxicity in rat proximal tubule epithelium in vivo.},
  author={Paul W. Sanders and Guillermo A. Herrera and John H. Galla},
  journal={Kidney international},
  year={1987},
  volume={32 6},
  pages={851-61}
}
To investigate the direct toxicity of human Bence Jones protein (BJP), individual nephrons of male Sprague-Dawley rats were perfused in vivo at 20 nl/min with an artificial tubule fluid (ATF) that contained no protein, a human kappa BJP (5 g/dl), or bovine serum albumin (5 g/dl), and proximal convoluted tubule function and morphology were examined. Perfusion with BJP perfusate for less than or equal to 5 minutes produced no changes (P = NS) in absorption of water, Jv, (1.09 +/- 0.20 vs. 1.50… CONTINUE READING
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