Human Barrett's adenocarcinoma of the esophagus, associated myofibroblasts, and endothelium can arise from bone marrow-derived cells after allogeneic stem cell transplant.

@article{Hutchinson2011HumanBA,
  title={Human Barrett's adenocarcinoma of the esophagus, associated myofibroblasts, and endothelium can arise from bone marrow-derived cells after allogeneic stem cell transplant.},
  author={Lloyd M Hutchinson and Bjorn Stenstrom and Duan Chen and Bilal Piperdi and Sara A Levey and Stephen Lyle and Timothy C Wang and Jeanmarie Houghton},
  journal={Stem cells and development},
  year={2011},
  volume={20 1},
  pages={11-7}
}
This study characterizes the contribution of bone marrow-derived cells (BMDCs) to Barrett's adenocarcinoma of the esophagus using a mouse surgical model of disease and human specimens. Transplantation of bone marrow expressing beta galactosidase into a wild-type mouse, followed by surgical esophagojejunostomy, allowed tracking of BMDCs into the surgical anastomosis and resulting Barrett's metaplasia. Human tissue from a male patient who had been transplanted with female bone marrow and later… CONTINUE READING

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