Human BIN3 complements the F-actin localization defects caused by loss of Hob3p, the fission yeast homolog of Rvs161p.

@article{Routhier2001HumanBC,
  title={Human BIN3 complements the F-actin localization defects caused by loss of Hob3p, the fission yeast homolog of Rvs161p.},
  author={Eric L. Routhier and Timothy C. Burn and I Abbaszade and Mia Summers and Charles F. Albright and George C Prendergast},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 24},
  pages={21670-7}
}
The BAR adaptor proteins encoded by the RVS167 and RVS161 genes from Saccharomyces cerevisiae form a complex that regulates actin, endocytosis, and viability following starvation or osmotic stress. In this study, we identified a human homolog of RVS161, termed BIN3 (bridging integrator-3), and a Schizosaccharomyces pombe homolog of RVS161, termed hob3+ (homolog of Bin3). In human tissues, the BIN3 gene was expressed ubiquitously except for brain. S. pombe cells lacking Hob3p were often… CONTINUE READING

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