Human B cell tolerance and its failure in rheumatoid arthritis.

@article{Samuels2005HumanBC,
  title={Human B cell tolerance and its failure in rheumatoid arthritis.},
  author={Jonathan Samuels and Yen-shing Ng and Claire Coupillaud and Daniel Paget and Eric Meffre},
  journal={Annals of the New York Academy of Sciences},
  year={2005},
  volume={1062},
  pages={
          116-26
        }
}
Random V(D)J gene assembly generates many autoreactive B cell receptors (BCRs). In healthy donors, most autoreactive developing B cells are removed either in the bone marrow or in the periphery, revealing two B cell tolerance checkpoints. The regulation and the mechanisms that ensure this human B cell tolerance are poorly characterized, but they require proper BCR signaling. Indeed, patients with X-linked agammaglobulinemia who carry mutations in the BTK gene, which encodes an essential BCR… CONTINUE READING

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