Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway.

@article{Mello2002HumanAA,
  title={Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway.},
  author={Jill A Mello and Herman H W Sillj{\'e} and Dani{\`e}le M.J. Roche and Doris B Kirschner and Erich A. Nigg and Genevi{\`e}ve Almouzni},
  journal={EMBO reports},
  year={2002},
  volume={3 4},
  pages={329-34}
}
The efficient assembly of newly replicated and repaired DNA into chromatin is essential for proper genome function. Based on genetic studies in Saccharomyces cerevisiae, the histone chaperone anti-silencing function 1 (Asf1) has been implicated in the DNA repair response. Here, the human homologs are shown to function synergistically with human CAF-1 to assemble nucleosomes during nucleotide excision repair in vitro. Furthermore, we demonstrate that hAsf1 proteins can interact directly with the… CONTINUE READING
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