Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.

@article{Meister2004HumanAM,
  title={Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.},
  author={Gunter Meister and Markus Landthaler and Agnieszka Patkaniowska and Yair Dorsett and Grace Teng and Thomas Tuschl},
  journal={Molecular cell},
  year={2004},
  volume={15 2},
  pages={185-97}
}
Argonaute proteins associate with small RNAs that guide mRNA degradation, translational repression, or a combination of both. The human Argonaute family has eight members, four of which (Ago1 through Ago4) are closely related and coexpressed in many cell types. To understand the biological function of the different Ago proteins, we set out to determine if Ago1 through Ago4 are associated with miRNAs as well as RISC activity in human cell lines. Our results suggest that miRNAs are incorporated… CONTINUE READING
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