Human Argonaute 2 Is Tethered to Ribosomal RNA through MicroRNA Interactions.

@article{Atwood2016HumanA2,
  title={Human Argonaute 2 Is Tethered to Ribosomal RNA through MicroRNA Interactions.},
  author={Blake L. Atwood and Jessica L. Woolnough and Gaelle M Lefevre and Mariana Saint Just Ribeiro and Gary Felsenfeld and Keith E. Giles},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 34},
  pages={17919-28}
}
The primary role of the RNAi machinery is to promote mRNA degradation within the cytoplasm in a microRNA-dependent manner. However, both Dicer and the Argonaute protein family have expanded roles in gene regulation within the nucleus. To further our understanding of this role, we have identified chromatin binding sites for AGO2 throughout the 45S region of the human rRNA gene. The location of these sites was mirrored by the positions of AGO2 cross-linking sites identified via PAR-CLIP-seq. AGO2… CONTINUE READING
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