Human Antibody Responses to Avian Influenza A(H7N9) Virus, 2013

  title={Human Antibody Responses to Avian Influenza A(H7N9) Virus, 2013},
  author={Li Guo and Xiaoying Zhang and Lili Ren and Xuelian Yu and Lijuan Chen and Hongli Zhou and Xin Gao and Zheng Teng and Jianguo Li and Jia-yu Hu and Chao Wu and Xia Xiao and Yiyi Zhu and Quanyi Wang and Xinghuo Pang and Qi Jin and Fan Wu and Jianwei Wang},
  booktitle={Emerging infectious diseases},
Understanding host antibody response is crucial for predicting disease severity and for vaccine development. We investigated antibody responses against influenza A(H7N9) virus in 48 serum samples from 21 patients, including paired samples from 15 patients. IgG against subtype H7 and neutralizing antibodies (NAbs) were not detected in acute-phase samples, but ELISA geometric mean titers increased in convalescent-phase samples; NAb titers were 20-80 (geometric mean titer 40). Avidity to IgG… CONTINUE READING
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