Human Anti-Plague Monoclonal Antibodies Protect Mice from Yersinia pestis in a Bubonic Plague Model

@inproceedings{Xiao2010HumanAM,
  title={Human Anti-Plague Monoclonal Antibodies Protect Mice from Yersinia pestis in a Bubonic Plague Model},
  author={Xiaodong Xiao and Zhongyu Zhu and Jennifer L. Dankmeyer and Michael M. Wormald and Randy Fast and Patricia L. Worsham and Christopher K. Cote and Kei Amemiya and D. S. Dimitrov},
  booktitle={PloS one},
  year={2010}
}
Yersinia pestis is the etiologic agent of plague that has killed more than 200 million people throughout the recorded history of mankind. Antibiotics may provide little immediate relief to patients who have a high bacteremia or to patients infected with an antibiotic resistant strain of plague. Two virulent factors of Y. pestis are the capsid F1 protein and the low-calcium response (Lcr) V-protein or V-antigen that have been proven to be the targets for both active and passive immunization… CONTINUE READING