Human Anti-Inflammatory Macrophages Induce Foxp3+GITR+CD25+ Regulatory T Cells, Which Suppress via Membrane-Bound TGFβ-11

@article{Savage2008HumanAM,
  title={Human Anti-Inflammatory Macrophages Induce Foxp3+GITR+CD25+ Regulatory T Cells, Which Suppress via Membrane-Bound TGF$\beta$-11},
  author={Nigel D. L. Savage and Tjitske de Boer and Kimberley V. Walburg and Simone A. Joosten and Krista E. van Meijgaarden and Annemieke Geluk and Tom H. M. Ottenhoff},
  journal={The Journal of Immunology},
  year={2008},
  volume={181},
  pages={2220 - 2226}
}
CD4+ T cell differentiation and function are critically dependent on the type of APC and the microenvironment in which Ag presentation occurs. Most studies have documented the effect of dendritic cells on effector and regulatory T cell differentiation; however, macrophages are the most abundant APCs in the periphery and can be found in virtually all organs and tissues. The effect of macrophages, and in particular their subsets, on T cell function has received little attention. Previously, we… Expand
Characterization of Protective Human CD4+CD25+ FOXP3+ Regulatory T Cells Generated with IL-2, TGF-β and Retinoic Acid
TLDR
A methodology is developed that induces human CD4+ cells to rapidly become stable, fully functional suppressor cells that are also resistant to proinflammatory cytokines and offers a practical novel strategy to treat human autoimmune diseases and prevent allograft rejection. Expand
Co-activation through TLR4 and TLR9 but not TLR2 skews Treg-mediated modulation of Igs and induces IL-17 secretion in Treg:B cell co-cultures
TLDR
The data indicate that under conditions like bacterial or viral infections, B cells can escape Treg control, and provides an explanation as to why patients suffering from allergy or helminth infections display polar immunopathological symptoms despite being exposed to the same agent. Expand
Cutting Edge: Human Latency-Associated Peptide+ T Cells: A Novel Regulatory T Cell Subset
TLDR
This study describes a unique population of T cells expressing a membrane bound form of TGF-β, the latency-associated peptide (LAP), and having regulatory properties in human peripheral blood that is different from classic CD4+Foxp3+CD25high natural Tregs. Expand
Macrophage Polarization Modulates FcγR- and CD13-Mediated Phagocytosis and Reactive Oxygen Species Production, Independently of Receptor Membrane Expression
TLDR
It is found that cytokine-mediated activation significantly and distinctively affected FcγR- and CD13-mediated phagocytosis and ROS generation and that activation of macrophages by each cytokine distinctly modulates expression ofphagocytic receptors, FcG antibodies, and ROS production. Expand
Allogeneic induced human FOXP3+IFN‐γ+ T cells exhibit selective suppressive capacity
TLDR
The induced human CD4+CD25+FOXP3+ subset derived from CD25− T cells, while expressing inflammatory cytokines, exhibits a suppressive cell contact‐dependent effect, restricted against T cells responding to the original stimulus. Expand
he activation status of human macrophages presenting antigen etermines the efficiency of Th 17 responses
Macrophages are antigen presenting cells that can adopt different activation states as directed by microenvironmental stimuli. It is well-recognised how CD4+ T helper (Th) signals drive macrophageExpand
The activation status of human macrophages presenting antigen determines the efficiency of Th17 responses.
TLDR
It is demonstrated for the first time how differentially activated human macrophages present antigen to bias specific, rather than mitogen-driven, Th responses and lead to propose that they impact adaptive immunity in vivo, particularly in determining Th17 polarisation within inflamed tissues. Expand
Ncf1 (p47phox) Is Essential for Direct Regulatory T Cell Mediated Suppression of CD4+ Effector T Cells
TLDR
Evidence is presented that NADPH oxidase derived ROS plays a role in the direct Treg mediated suppression of CD4+ effector T cells in a process that is blocked by thiol-containing antioxidants, NAD PH oxidase inhibitors or a lack of Ncf1 expression in Tregs and Teffs. Expand
CSF-1–Dependent Red Pulp Macrophages Regulate CD4 T Cell Responses
TLDR
Results suggested that splenic CSF-1–dependent F4/80hiMac-1low MΦs are a subpopulation of RPMs and regulate peripheral immune homeostasis. Expand
CD8lowCD28– T Cells: A Human CD8 T-Suppressor Subpopulation with Alloantigen Specificity Induced by Soluble HLA-A2 Dimer in Vitro
TLDR
It is demonstrated that soluble HLA-A2 dimer could efficiently induce the tolerant CD8lowCD28– T cells with alloantigen-specific suppression on alloreactive T cells in a cell–cell contact-dependent fashion. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 33 REFERENCES
Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β
CD4+CD25+ T cells have been identified as a population of immunoregulatory T cells, which mediate suppression of CD4+CD25− T cells by cell–cell contact and not secretion of suppressor cytokines. InExpand
Identification of a human CD8+ regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4
TLDR
A human CD8+lymphocyte activation gene-3 (LAG-3)+CD25+FoxP3+ Treg subset, which suppresses T cells partly through the secretion of CC chemokine ligand 4 (CCL4), which can inhibit T cell activation by interfering with T cell receptor signaling, may play a role in immunoregulation in humans, including infectious diseases. Expand
IFN-α and IL-10 Induce the Differentiation of Human Type 1 T Regulatory Cells1
TLDR
It is demonstrated that IFN-α strongly enhances IL-10-induced differentiation of functional Tr1 cells, which represents a first major step in establishing specific culture conditions to generate T regulatory cells for biological and biochemical analysis, and for cellular therapy to induce peripheral tolerance in humans. Expand
TGF-β-Mediated Suppression by CD4+CD25+ T Cells Is Facilitated by CTLA-4 Signaling
TLDR
It is shown with confocal fluorescence microscopy that incubation of CD4+CD25+ T cells with anti-CTLA-4- and rB7-1/Fc-coated beads results in accumulation of TGF-β at the cell-bead contact site, which suggests that CTLA- 4 signaling facilitates T GF-β-mediated suppression by intensifying the TGF -β signal at the point of suppressor cell-target cell interaction. Expand
Monocyte-Derived Human Macrophages Mediate Anergy in Allogeneic T Cells and Induce Regulatory T Cells1
TLDR
It is demonstrated that M φ drive the differentiation of regulatory T cells and mediate anergy in allogeneic T cells, supporting the concept that Mφ maintain peripheral tolerance in vivo. Expand
TGF-β1 Plays an Important Role in the Mechanism of CD4+CD25+ Regulatory T Cell Activity in Both Humans and Mice
TLDR
It is demonstrated that TGF-β1 produced by CD4+CD25+ T cells is involved in the suppressor activity of these cells, particularly in their ability to regulate intestinal inflammation. Expand
Human peritoneal macrophages show functional characteristics of M‐CSF‐driven anti‐inflammatory type 2 macrophages
TLDR
The data provide the evidence for the first time that in vitro polarized MΦ2 exist in vivo, and human pMΦ resemble the anti‐inflammatory M Φ2, and it is proposed that pM Φ have the potential to maintain an anti-inflammatory condition in the peritoneal cavity. Expand
Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype.
TLDR
It is demonstrated here that TCR stimulation alone was insufficient to induce Foxp3 expression in the absence of TGFbeta, whereas high levels of FOXP3 expression could be induced in the presence of T GFbeta, and this results suggest that even high Levels of FoxP3expression are insufficient to define a human CD4+ T cell as a T-regulatory cell. Expand
Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR.
TLDR
Results suggest that in addition to controlling memory T-cell numbers, OX40 directly controls T reg-mediated suppression of graft-versus-host disease. Expand
TGF-β: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression
TLDR
Collectively, multiple previously unconnected puzzle pieces are beginning to be linked into a more coherent, albeit incomplete picture of CD4 + CD25 + T cell-mediated suppression of antigen-activated T cells. Expand
...
1
2
3
4
...