Human Airway Smooth Muscle Cells Express the High Affinity Receptor for IgE (FcεRI): A Critical Role of FcεRI in Human Airway Smooth Muscle Cell Function

@inproceedings{Gounni2005HumanAS,
  title={Human Airway Smooth Muscle Cells Express the High Affinity Receptor for IgE (FcεRI): A Critical Role of FcεRI in Human Airway Smooth Muscle Cell Function},
  author={Abdelilah S Gounni and Vincent Wellemans and James J. Yang and Fabienne Bellesort and Kamrouz Kassiri and Sophie C Gangloff and Moncef Guenounou and Andrew J Halayko and Qutayba Hamid Hamid and Bouchaib Lamkhioued},
  year={2005}
}
Several reports suggest that activated airway smooth muscle (ASM) cells are capable of generating various proinflammatory mediators, including cytokines and chemokines. However, little is known about the mechanism involved in this process. In this regard, we have examined the expression and the role of the high affinity IgE receptor (FceRI) by ASM cells. Human ASM cells were found to constitutively express transcripts coding for α, β, and γ subunits of FceRI. Flow cytometry and Western blot… CONTINUE READING

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