Human Acyl-CoA: Cholesterol acyltransferase (hACAT)-inhibiting triterpenes from Lythrum salicaria L.

@article{Lee2011HumanAC,
  title={Human Acyl-CoA: Cholesterol acyltransferase (hACAT)-inhibiting triterpenes from Lythrum salicaria L.},
  author={Sang Hyuk Lee and Seung Eun Lee and Tae-Sook Jeong and 최애진 and Jung ‐ Sook Sung and Jung Bong Kim and Yoon Hong and Young Choong Kim and Kyeongseop Song},
  journal={Journal of the Korean Society for Applied Biological Chemistry},
  year={2011},
  volume={54},
  pages={628-632}
}
Abstractβ-Sitosterol (1), betulinic acid (2), and 3β-hydroxy-20(29)-lupen-28-oic acid methyl ester (3) were isolated from the herbal parts of Lythrum salicaria. Compounds 2 and 3 were isolated for the first time from L. salicaria and they showed inhibitory activities on both hACAT1 and hACAT2. These results suggested that L. salicaria, which contains triterpenes 2 and 3, might be effective in the prevention and treatment of hypercholesterolemia or atherosclerosis due to its inhibitory effect on… CONTINUE READING

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