Human APOBEC3G can restrict retroviral infection in avian cells and acts independently of both UNG and SMUG1.

@article{Langlois2008HumanAC,
  title={Human APOBEC3G can restrict retroviral infection in avian cells and acts independently of both UNG and SMUG1.},
  author={Marc-Andr{\'e} Langlois and Michael Neuberger},
  journal={Journal of virology},
  year={2008},
  volume={82 9},
  pages={4660-4}
}
APOBEC3 proteins are mammal-specific cytidine deaminases that can restrict retroviral infection. The exact mechanism of the restriction remains unresolved, but one model envisions that uracilated retroviral cDNA, generated by cytidine deamination, is the target of cellular glycosylases. While restriction is unaffected by UNG deficiency, it has been suggested that the SMUG1 glycosylase might provide a backup. We found that retroviral restriction can be achieved by introducing human APOBEC3G into… CONTINUE READING
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