Human APOBEC3 Induced Mutation of Human Immunodeficiency Virus Type-1 Contributes to Adaptation and Evolution in Natural Infection

@inproceedings{Kim2014HumanAI,
  title={Human APOBEC3 Induced Mutation of Human Immunodeficiency Virus Type-1 Contributes to Adaptation and Evolution in Natural Infection},
  author={Eun-Young Kim and Ram{\'o}n Lorenzo-Redondo and Susan J. Little and Yoon-Seok Chung and Prabhjeet K. Phalora and Irina Maljkovic Berry and John Archer and S Prasad Penugonda and Will Fischer and Douglas D. Richman and Tanmoy Bhattacharya and Michael H Malim and Steven M. Wolinsky},
  booktitle={PLoS pathogens},
  year={2014}
}
Human APOBEC3 proteins are cytidine deaminases that contribute broadly to innate immunity through the control of exogenous retrovirus replication and endogenous retroelement retrotransposition. As an intrinsic antiretroviral defense mechanism, APOBEC3 proteins induce extensive guanosine-to-adenosine (G-to-A) mutagenesis and inhibit synthesis of nascent human immunodeficiency virus-type 1 (HIV-1) cDNA. Human APOBEC3 proteins have additionally been proposed to induce infrequent, potentially non… CONTINUE READING
Highly Cited
This paper has 35 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 3 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

Perspective: APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution

Annals of oncology : official journal of the European Society for Medical Oncology • 2018

References

Publications referenced by this paper.
Showing 1-10 of 68 references

HIV Signature and Sequence Variation Analysis. Computational Analysis of HIV Molecular Sequences

B Korber
eds. ed. Dordrecht, • 2000
View 3 Excerpts
Highly Influenced

HIV Sequence Compendium

B LTFoley, C Apetrei, +5 authors B Korber
2013
View 3 Excerpts
Highly Influenced

binom: Binomial Confidence Intervals For Several Parameterizations

S Dorai-Raj
2014