Human AP endonuclease suppresses DNA mismatch repair activity leading to microsatellite instability

@article{Chang2005HumanAE,
  title={Human AP endonuclease suppresses DNA mismatch repair activity leading to microsatellite instability},
  author={In-Youb Chang and Soo-Hyun Kim and Hyun-ju Cho and Do Young Lee and Mi-Hwa Kim and M R Chung and Ho Jin You},
  journal={Nucleic Acids Research},
  year={2005},
  volume={33},
  pages={5073 - 5081}
}
The multifunctional mammalian apurinic/apyrimidinic (AP) endonuclease (APE) participates in the repair of AP sites in the cellular DNA as well as participating in the redox regulation of the transcription factor function. The function of APE is considered as the rate-limiting step in DNA base excision repair. Paradoxically, an unbalanced increase in APE protein leads to genetic instability. Therefore, we investigated the mechanisms of genetic instability that are induced by APE. Here, we report… CONTINUE READING

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