Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family.

@article{Hammond1995HumanAF,
  title={Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family.},
  author={Scott M. Hammond and Yelena M. Altshuller and T C Sung and Simon A. Rudge and Karsten Rose and JoAnne Engebrecht and Andrew J. Morris and Michael A. Frohman},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 50},
  pages={29640-3}
}
Activation of phosphatidylcholine-specific phospholipase D (PLD) has been implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. We report here the identification of the first human PLD cDNA, which defines a new and highly conserved gene family. Characterization of recombinant human PLD1 reveals that it is membrane-associated, selective for phosphatidylcholine, stimulated by phosphatidylinositol 4,5… CONTINUE READING
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