Human ABCG2: structure, function, and its role in multidrug resistance.

  title={Human ABCG2: structure, function, and its role in multidrug resistance.},
  author={Wei Dong Mo and Jian-Ting Zhang},
  journal={International journal of biochemistry and molecular biology},
  volume={3 1},
Human ABCG2 is a member of the ATP-binding cassette (ABC) transporter superfamily and is known to contribute to multidrug resistance (MDR) in cancer chemotherapy. Among ABC transporters that are known to cause MDR, ABCG2 is particularly interesting for its potential role in protecting cancer stem cells and its complex oligomeric structure. Recent studies have also revealed that the biogenesis of ABCG2 could be modulated by small molecule compounds. These modulators, upon binding to ABCG2… CONTINUE READING

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