Human 60-kDa lysophospholipase contains an N-terminal L-asparaginase domain that is allosterically regulated by L-asparagine.

@article{Karamitros2014Human6L,
  title={Human 60-kDa lysophospholipase contains an N-terminal L-asparaginase domain that is allosterically regulated by L-asparagine.},
  author={Christos S. Karamitros and M. HadeJ M. Konrad},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 19},
  pages={12962-75}
}
The structural and functional characterization of human enzymes that are of potential medical and therapeutic interest is of prime significance for translational research. One of the most notable examples of a therapeutic enzyme is L-asparaginase, which has been established as an antileukemic protein drug for more than four decades. Up until now, only… CONTINUE READING