Human 3-methyladenine-DNA glycosylase: effect of sequence context on excision, association with PCNA, and stimulation by AP endonuclease.

@article{Xia2005Human3G,
  title={Human 3-methyladenine-DNA glycosylase: effect of sequence context on excision, association with PCNA, and stimulation by AP endonuclease.},
  author={Liqun Xia and Li Zheng and Hyun-Wook Lee and Steven E. Bates and Laura E. Federico and Binghui Shen and T. R. O'Connor},
  journal={Journal of molecular biology},
  year={2005},
  volume={346 5},
  pages={1259-74}
}
Human 3-methyladenine-DNA glycosylase (MPG protein) is involved in the base excision repair (BER) pathway responsible mainly for the repair of small DNA base modifications. It initiates BER by recognizing DNA adducts and cleaving the glycosylic bond leaving an abasic site. Here, we explore several of the factors that could influence excision of adducts recognized by MPG, including sequence context, effect of APE1, and interaction with other proteins. To investigate sequence context, we used 13… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

Morphological effects of mitomycin C on urothelial responses to experimentally-induced urethral stricture in rats.

International journal of urology : official journal of the Japanese Urological Association • 2015

Similar Papers

Loading similar papers…