Human 17beta-hydroxysteroid dehydrogenases types 1, 2, and 3 catalyze bi-directional equilibrium reactions, rather than unidirectional metabolism, in HEK-293 cells.

@article{Khan2004Human1D,
  title={Human 17beta-hydroxysteroid dehydrogenases types 1, 2, and 3 catalyze bi-directional equilibrium reactions, rather than unidirectional metabolism, in HEK-293 cells.},
  author={Naveed Khan and Kamalesh Kumar Sharma and Stefan Andersson and Richard J Auchus},
  journal={Archives of biochemistry and biophysics},
  year={2004},
  volume={429 1},
  pages={50-9}
}
Human 17beta-hydroxysteroid dehydrogenases (17betaHSDs) catalyze the interconversion of weak and potent androgen and estrogen pairs. Although the reactions using purified enzymes can be driven in either direction, these enzymes appear to function unidirectionally in intact cells: only reductive reactions for 17betaHSD1 and 17beta HSD3 and only oxidative… CONTINUE READING