Human (non‐severe acute respiratory syndrome) coronavirus infections in hospitalised children in France

@article{Vabret2008HumanA,
  title={Human (non‐severe acute respiratory syndrome) coronavirus infections in hospitalised children in France},
  author={Astrid Vabret and Julia Dina and Stéphanie Gouarin and Jo{\"e}lle Petitjean and Val{\'e}rie Tripey and Jacques Brouard and François Freymuth},
  journal={Journal of Paediatrics and Child Health},
  year={2008},
  volume={44},
  pages={176 - 181}
}
Aim:  This study has two objectives: to study the clinical symptoms associated with the detection of the four human coronaviruses (HCoVs), 229E, OC43, NL63 and HKU1 types, in the respiratory specimens sampled from hospitalised children in France between September 2004 and May 2005; and to develop a multiplex reverse transcription polymerase chain reaction (RT‐PCR) assay allowing for the simultaneous detection of the four HCoVs. 
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100 Citations
Highly Influential Citations
4
Background Citations
38
Methods Citations
4
Results Citations
7

100 Citations

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HCoVs could play significant role in causing upper respiratory tract infections among adults and older children in rural areas of Ghana and were found to be seasonally dependent with significant detections in the harmattan season and wet season.
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A case of radiologically demonstrated CoV HKU 1-related bronchiolitis with acute respiratory failure in an adult female without significant comorbidities except obesity is described.
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HCoV clinical symptoms were more severe than those of RSV infections but milder than influenza symptoms, and while it was absent from the public winter survey, 22.6% of the patients were HCoV-HKU1 positives, mainly during the spring-summer period.
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HCoVs are associated with a substantial burden of RTIs in hospitalized children in need of hospitalization and a high HCoV genomic load was associated with RTI.
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