Human β-defensin 3 contains an oncolytic motif that binds PI(4,5)P2 to mediate tumour cell permeabilisation

@inproceedings{Phan2016Human3,
  title={Human β-defensin 3 contains an oncolytic motif that binds PI(4,5)P2 to mediate tumour cell permeabilisation},
  author={Thanh Kha Phan and Fung T Lay and Ivan K H Poon and Mark G. Hinds and Marc Kvansakul and Mark D Hulett},
  booktitle={Oncotarget},
  year={2016}
}
Cationic antimicrobial peptides (CAPs), including taxonomically diverse defensins, are innate defense molecules that display potent antimicrobial and immunomodulatory activities. Specific CAPs have also been shown to possess anticancer activities; however, their mechanisms of action are not well defined. Recently, the plant defensin NaD1 was shown to induce… CONTINUE READING