Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes.

@article{Moran2012HumanC,
  title={Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes.},
  author={Ignasi Moran and Ildem Akerman and Martijn van de Bunt and Ruiyu Xie and Marion Benazra and Takao Nammo and Luis Arnes and Nikolina Naki{\'c} and Javier Garc{\'i}a-Hurtado and Santiago A. Rodr{\'i}guez-Segu{\'i} and Lorenzo Pasquali and Claire Sauty-Colace and Anthony Beucher and Rapha{\"e}l Scharfmann and Joris van Arensbergen and Paul R Johnson and Andrew Berry and Clarence Lee and Timothy Harkins and Val{\'e}ry Gmyr and François Pattou and Julie Kerr-conte and Lorenzo Piemonti and Thierry Berney and Neil Hanley and Anna L Gloyn and Lori Sussel and Linda W Langman and K L Brayman and Maike Sander and Mark I. McCarthy and Philippe Ravassard and Jorge Ferrer},
  journal={Cell metabolism},
  year={2012},
  volume={16 4},
  pages={435-48}
}
A significant portion of the genome is transcribed as long noncoding RNAs (lncRNAs), several of which are known to control gene expression. The repertoire and regulation of lncRNAs in disease-relevant tissues, however, has not been systematically explored. We report a comprehensive strand-specific transcriptome map of human pancreatic islets and β cells, and uncover >1100 intergenic and antisense islet-cell lncRNA genes. We find islet lncRNAs that are dynamically regulated and show that they… CONTINUE READING