Human β 1- and β 2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes

@article{Frielle1988Human,
  title={Human $\beta$
 1- and $\beta$
 2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes},
  author={Thomas Frielle and Brian K. Kobilka and Robert J. Lefkowitz and Marc G. Caron},
  journal={Trends in Neurosciences},
  year={1988},
  volume={11},
  pages={321-324}
}
View on Elsevier
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27 Citations
Background Citations
1
Methods Citations
1

27 Citations

Probing human β1- and β2-adrenoceptors with domain-specific fusion protein antibodies
Differences in desensitization between human β1- and β2-adrenergic receptors stably expressed in transfected hamster cells
Bioamine receptors: evolutionary and functional variations of a structural leitmotiv.
TLDR
The main conformational and functional constraints exerted on the structure of the bioamine receptors are reviewed, mainly the transmembrane conformation of the receptors, their ability to bind ligands, to interact with G-proteins and to desensitize.
Development of β-adrenergic receptor and G protein messenger RNA in rat brain
Transcription of the rat beta 1-adrenergic receptor gene. Characterization of the transcript and identification of important sequences.
TLDR
Characterization of the rat beta 1-adrenergic receptor transcript by transient transfection analysis has identified a region between bases -389 and -325 which is necessary for expression and the specific deletion of a potentially functional inverted CCAAT sequence within this region does not significantly alter activity.
Antidepressant-induced Switch of β1-Adrenoceptor Trafficking as a Mechanism for Drug Action*
TLDR
The data suggest a new mode of drug action causing a “switch” of receptor fate from a fast recycling pathway to a slowly exchanging perinuclear compartment.
Is there a third heart β-adrenoceptor?
Regulation of β1‐Adrenergic Receptor mRNA and Ligand Binding by Antidepressant Treatments and Norepinephrine Depletion in Rat Frontal Cortex
TLDR
The results demonstrate that β1AR mRNA and ligand binding are regulated in parallel by ECS treatment but that levels of receptor mRNA areregulated in a complex manner by imipramine or 6‐OHDA treatments, not predicted by changes in ligandbinding.
Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor.
  • Y. Tang, L. Hu, R. Lefkowitz
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1999
TLDR
The studies demonstrate a role of the SH3p4/p8/p13 protein family in beta1-AR signaling and suggest that interaction between proline-rich motifs and SH3-containing proteins may represent a previously underappreciated aspect of G-protein coupled receptor signaling.
Cloning, Expression of the Human Substance K Receptor, and Analysis of Its Role in Mitogenesis
TLDR
The human substance K receptor can function as a growth fador receptor when expressed in mouse 3T3 cells and has an apparent molecular weight of 45,000, consistent with little or no N-linked glycosylation.
...
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References

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The pharmacology of the expressed receptors indicates that most of the hydrophilic residues are not directly involved in the binding of agonists or antagonists to the receptor, and a mutant receptor is identified that has high agonist affinity but does not couple to adenylate cyclase.
Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin
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Cloning of the gene and cDNA for the mammalian β2AR indicates significant amino-acid homology with bovine rhodopin and suggests that, like rhodopsin7, βAR possesses multiple membrane-spanning regions.
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