Human α1-proteinase inhibitor (Respreeza®) in α1-antitrypsin deficiency emphysema: a guide to its use in the EU

@article{McKeage2016HumanI,
  title={Human $\alpha$1-proteinase inhibitor (Respreeza{\textregistered}) in $\alpha$1-antitrypsin deficiency emphysema: a guide to its use in the EU},
  author={Kate McKeage and Katherine A. Lyseng-Williamson},
  journal={Drugs \& Therapy Perspectives},
  year={2016},
  volume={32},
  pages={422-427}
}
Augmentation with intravenous infusions of human α1-proteinase inhibitor [Respreeza® (EU); Zemaira® (USA)] slows the progression of emphysema in patients with severe α1-antitrypsin (AAT)-deficiency emphysema. In the randomized, double-blind RAPID trial in patients with severe AAT-deficiency emphysema, Respreeza®/Zemaira® significantly reduced the mean annual rate of lung density loss based on computed tomography imaging at total lung capacity (TLC), but not at functional residual capacity (FRC… Expand
1 Citations
Human α1-proteinase inhibitor (Respreeza®) in α1-antitrypsin deficiency emphysema: a profile of its use in the EU
TLDR
The continued efficacy of Respreeza in slowing the progression of emphysema was demonstrated in a 2-year open-label extension of the RAPID trial, and lung density loss prior to treatment was not recovered. Expand

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