Human α1-adrenoceptor subtype selectivity of substituted homobivalent 4-aminoquinolines.


A series of ring-substituted ethyl- and heptyl-linked 4-aminoquinoline dimers were synthesized and evaluated for their affinities at the 3 human α(1)-adrenoceptor (α(1)-AR) subtypes and the human serotonin 5-HT(1A)-receptor (5-HT(1A)-R). We find that the structure-specificity profiles are different for the two series at the α(1)-AR subtypes, which suggests… (More)
DOI: 10.1016/j.bmc.2014.09.017

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